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The Science

Your Window to Healthy Aging Research

Aging research and scientific articles exploring longevity, innovations, causes of aging, neurodegenerative diseases, immunosenescence & cell damage.

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Hallmarks of Aging

The Hallmarks of Aging: Science Brings New Insights and Optimism to Human Longevity

We are learning more about how the human body ages and, in the process, what might be done to slow it down or even reverse it. This guide to the Hallmarks of Aging begins to explain the new power and innovation science will bring us.

September 30, 2020

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Metabolic Health

The Science Behind Juvenescence's Breakthrough Product: Metabolic Switch

Recent developments in aging biology have revealed a beneficial role for ketones in healthspan. Juvenescence and scientists at the Buck Institute have developed an exogenous ketone product that lets anyone achieve the benefits of ketosis.

September 30, 2020

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Regeneration

Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure

Human liver disease is modeled in swine. Liver cells transplanted, forming ectopic livers that cured fatal disease.

September 11, 2020

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Regeneration

Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes

Transplanted swine liver cells are engrafted into the lymph nodes, proliferated, and form ectopic mini-livers.

August 18, 2020

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Ketosis & Metabolism

β-hydroxybutyrate and its Metabolic Effects on Age-associated Pathology

Aging is a universal and irreversible process that renders individuals vulnerable to many diseases. Increased β-HB has been reported to prevent or improve symptoms of various age-associated diseases.

April 7, 2020

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Regeneration

Engineering strategies for generating hypoimmunogenic cells with high clinical and commercial value

The engineering of allogeneic cells to be ‘hypoimmunogenic’, also referred to as ‘universal’, so that they evade a host's immune system would be transformative for regenerative medicine.

October 29, 2019

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Data Science

Deep learning enables rapid identification of potent DDR1 kinase inhibitors

Development of a deep generative model, generative tensorial reinforcement learning (GENTRL), for de novo small-molecule design, optimizes synthetic feasibility, novelty, and biological activity.

September 1, 2019

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Regeneration

Toward a unified theory of aging and regeneration

A unified model of aging and loss of regenerative potential is emerging that may ultimately be translated into new therapeutic approaches for establishing induced tissue regeneration and modulation of the embryo-onco phenotype of cancer.

August 27, 2019

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Regeneration

Host Lymphotoxin-β Receptor Signaling Is Crucial for Angiogenesis of Metanephric Tissue Transplanted into Lymphoid Sites

Unraveling some of the molecular signaling that appears to be crucial for engrafted kidney tissue to grow.

August 18, 2019

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Regeneration

Kidney‐in‐a‐lymph node: A novel organogenesis assay to model human renal development and test nephron progenitor cell...

Expands upon findings in mice that show human ectopic kidney tissues can be grown using the lymph node as a bioreactor.

July 2, 2019

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Regeneration

Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells

Exploration of an alternative approach involving the identification of clonal self-renewing human embryonic progenitor (hEP) cell lines following partial hPS cell differentiation and selection of scalable clones.

January 7, 2019

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Ketosis & Metabolism

On the Metabolism of Exogenous Ketones in Humans

Traditionally, ketosis has been achieved by following a “ketogenic” diet, but an alternative way to increase blood D-β-hydroxybutyrate (D-βHB) concentrations is ketone drinks, which effectively raise blood ketone concentrations.

October 29, 2017

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Ketosis & Metabolism

A Ketone Ester Drink Lowers Human Ghrelin and Appetite

The ketones D-β-hydroxybutyrate (D-βHB) and acetoacetate are elevated during prolonged fast- ing or during a ketogenic diet. An exogenous ketone ester suppresses the appetite hormone ghrelin and lowers perceived hunger and desire to eat.

October 5, 2017

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Ketosis & Metabolism

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

Ketogenic diets (KD) may have similar metabolic effects to dietary caloric restriction. A cyclic KD improves midlife survival and memory performance in aging mice, without affecting maximal lifespan.

September 4, 2017

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Ketosis & Metabolism

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Concentrations of endogenous metabolites affect histone acetylation and thereby couple cellular metabolic status and transcriptional regulation. β-HB is an inhibitor of histone deacetylase (HDAC) and protects against oxidative stress.

January 10, 2013

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