Ketosis, Metabolism & Aging

Metabolic Health

The Science Behind Juvenescence's Breakthrough Product: Metabolic Switch

Recent developments in aging biology have revealed a beneficial role for ketones in healthspan. Juvenescence and scientists at the Buck Institute have developed an exogenous ketone product that lets anyone achieve the benefits of ketosis.

September 30, 2020

Ketosis & Metabolism

β-hydroxybutyrate and its Metabolic Effects on Age-associated Pathology

Aging is a universal and irreversible process that renders individuals vulnerable to many diseases. Increased β-HB has been reported to prevent or improve symptoms of various age-associated diseases.

April 7, 2020

Ketosis & Metabolism

On the Metabolism of Exogenous Ketones in Humans

Traditionally, ketosis has been achieved by following a “ketogenic” diet, but an alternative way to increase blood D-β-hydroxybutyrate (D-βHB) concentrations is ketone drinks, which effectively raise blood ketone concentrations.

October 29, 2017

Ketosis & Metabolism

A Ketone Ester Drink Lowers Human Ghrelin and Appetite

The ketones D-β-hydroxybutyrate (D-βHB) and acetoacetate are elevated during prolonged fast- ing or during a ketogenic diet. An exogenous ketone ester suppresses the appetite hormone ghrelin and lowers perceived hunger and desire to eat.

October 5, 2017

Ketosis & Metabolism

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

Ketogenic diets (KD) may have similar metabolic effects to dietary caloric restriction. A cyclic KD improves midlife survival and memory performance in aging mice, without affecting maximal lifespan.

September 4, 2017

Ketosis & Metabolism

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Concentrations of endogenous metabolites affect histone acetylation and thereby couple cellular metabolic status and transcriptional regulation. β-HB is an inhibitor of histone deacetylase (HDAC) and protects against oxidative stress.

January 10, 2013