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Ketosis & Metabolism

On the Metabolism of Exogenous Ketones in Humans

By Dr. Brianna Stubbs, DPhil, Pete J. Cox, Rhys D. Evans et al

The benefits of ketogenic diets for neurological conditions, weight loss, and cognitive function are driven by ketone bodies, namely Beta-Hydroxybutyrate (β-HB) and acetoacetate (AcAc), which are produced during fasting, starvation, or exercise in response to low-glucose availability. Recent evidence suggests that β-HB has molecular signaling actions that could benefit aging and metabolic health. Exogenous ketone esters (KE) and ketone salts (KS) provide a way to deliver ketones in the absence of ketogenic diets or fasting while providing the benefits associated with these dietary regimens. Consuming KE and KS elevated blood β-HB levels rapidly, but β-HB was >50% higher after KE vs. KS. Eating a meal before KE or KS reduced the elevation in β-HB. Continuous dosing of KE maintained nutritional ketosis for 9 hours. Exogenous ketones are an effective way to rapidly induce ketosis, and their use as a “dietary supplement” may mimic the healthspan effects of ketogenic diets and fasting.

View the full peer-reviewed scientific paper at Frontiers in Physiology.

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