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Regeneration

Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure

By Clara T. Nicolas, Robert A. Kaiser, Raymond D. Hickey, Kari L. Allen et al

In this study, a human liver disease (tyrosinemia Type I) was modeled in swine, and liver cells transplanted into lymph nodes were capable of forming ectopic livers that cured all of the animals of otherwise fatal liver disease. The engraftments were shown to be safe and also structurally and functionally similar to native liver tissue.

View the full peer-reviewed scientific paper at ScienceDirect.

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