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Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes

By Paulo Fontes, Junji Komori, Robert Lopez, Wallis March et al

In this swine model using surgically-induced liver injuries, liver cells were isolated from the animals and then transplanted into lymph nodes in the abdominal region of the animal. In 100% of the animals the transplanted liver cells engrafted into the lymph nodes, proliferated, and formed ectopic mini-livers, which had the same structure and function as native liver tissue.

View the full peer-reviewed scientific paper at National Institutes of Health.

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