Our Organization LyGenesis, Inc.
Our Organization LyGenesis, Inc.
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LyGenesis, Inc.

This developing technology will allow patients to regrow tissues in their own body, possibly revolutionizing the transplant market.



A spinout from University of Pittsburgh’s McGowan Institute for Regenerative Medicine, LyGenesis, Inc.’s technology enables the use of a patient’s own lymph nodes to act as bioreactors to regrow functioning ectopic organs including liver, kidney, thymus, and pancreas.

The initial target for clinical development is liver regeneration, with a focus on helping patients with end-stage liver disease (ESLD) using a hepatocyte cell therapy product implanted into periduodenal lymph nodes.

LyGenesis’ technology allows a single donated liver to act as the seed for dozens of transplants using outpatient endoscopy to engraft the cells. These allogeneic hepatocytes engraft, vascularize, and perform all of the functions typical to liver tissue, enabling them to rescue patients from ESLD.

LyGenesis’ innovative work could revolutionize the transplant market, allowing patients to potentially avoid a liver transplant, or extending the lifespan of those ineligible for a liver transplant.

Classified as a cell therapy by the FDA, LyGenesis represents a near-term, real world example of regenerative medicine. Moreover, the ability of its organogenesis platform to regenerate functioning thymus, pancreas and renal tissues opens up a broad array of potential clinical indications. Second generation therapies using gene-modified cells could help to create off-the-shelf therapies, which could reduce or eliminate the need for immune suppression.

In the News

LyGenesis

Longevity Technology: 'Hufford interview: “It’s worth pointing out just how remarkable this is.”'

LyGenesis CEO Michael Hufford talks to Longevity Technology about Longevity research programs and investment.

July 22, 2020

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LyGenesis

LyGenesis Announces Four Peer-Reviewed Publications on its Organ Regeneration Technology

LyGenesis announces four new peer-reviewed publications highlighting its advancing technology for kidney and liver regeneration.

August 27, 2020

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LyGenesis

LyGenesis Closes $4 Million Convertible Debt Financing to Begin Clinical Development of Liver Regeneration Technology

LyGenesis, a Juvenescence partner, focused on organ regeneration, announced that they have completed a total of $4 million in private financing of convertible notes from Juvenescence, and the Longevity Vision Fund.

October 20, 2019

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